Scientists have known insects. Experience. Greg Neely and colleagues at the University of Sydney for the first time.
The study in the peer-reviewed journal Science Advances offers the first genetic evidence of Drosophila (fruit flies). Ongoing research into these mechanisms could lead to the development of chronic pain.
"I can help you," said Associate Professor Neely, whose team is studying Charles Perkins. Center with the goal of developing non-opioid solutions for pain management.
Pain and insects
"People do not really think of any kind of pain," said Associate Professor Neely. "Invisible", "inseparable", "insecure", "insecure", "insecure". , or physical injury, but for simplicity, we can refer to what an insects experience as 'pain'. "
"So we knew that insects could sense 'pain', but it is not possible for human patients' experiences.
What is chronic pain?
Chronic pain is defined as persistent pain. It comes in two forms: inflammatory pain and neuropathic pain.
The study of fruit flies at neuropathic 'pain', which breaks down the nervous system, and in others, is usually described as a burning or shooting pain. Neuropathic pain can occur in human conditions such as sciatica, pinched nerve, spinal cord injuries, postherpetic neuralgia (shingles), diabetic neuropathy, cancer bone pain, and accidental injuries.
Testing pain in fruit flies
In the study, Associate Professor Neely and lead author Dr Thang Khuong from the University of Charles Perkins Center, damaged and nerve in one leg of the fly. The injury was then allowed to fully heal. After the injury, healed, they have become hypersensitive. "Said the Associate Professor Neely. "That's kind of cool and intuitive."
Next, the team genetically dissected exactly how that works.
'The fly is receiving' pain 'messages from the body, then the nerve cord, the fly' s version of our spinal cord. pain perception based on the context, "Associate Professor Neely said. "After the injury, the injured nerve dumps all the cargo in the nerve, and the lack of pain in the forefront. are hypervigilant. "
"Animals need to lose the pain" lack of survival in dangerous situations. "We need to get the lack of back to live and comfortable and non-painful existence."
In humans, chronic pain is presumed to develop a peripheral sensitization or central disinhibition, said Associate Professor Neely. "From our unbiased genomic dissection of neuropathic pain in all our health."
"Importantly now we know the critical step in the process of neuropathic pain in flies, mice and people, and stop pain for good. "
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